Stem cells in pulmonary alveolar regeneration

CHROMOSOMAL PROTEINS IN PULMONARY ALVEOLAR MACROPHAGES

In this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. Cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. Proteins were then analysed on SDS polyacrylamide gels and densitometric...

Estrogen regulates pulmonary alveolar formation, loss, and regeneration in mice.

Lung tissue elastic recoil and the dimension and number of pulmonary gas-exchange units (alveoli) are major determinants of gas-exchange function. Loss of gas-exchange function accelerates after menopause in the healthy aged and is progressively lost in individuals with chronic obstructive pulmonary disease (COPD). The latter, a disease of midlife and later, though more common in men than in wo...

Stem Cells in Cartilage Regeneration

Cartilage is one of the chief structural tissues in the human body. Being resilient and smooth, it covers and protects the ends of long bones providing points of articulation at the joints and is a principal constituent of the rib cage, the ear, the nose, the bronchial tubes, the intervertebral discs, and many other body components [1]. It is not as hard and rigid as bone, but it is stiffer and...

Amniotic Fluid Stem Cells and Their Application in Cell-Based Tissue Regeneration

Alveolar stem cells in canine bronchial carcinogenesis.

Alveolar type II cells are not present in normal epithelium of canine segmental bronchi but after carcinogen exposure they do occur in intra-epithelial lesions with all degrees of atypia and in invasive lesions with different glandular growth patterns. Immunohistochemistry for proliferation markers (PCNA; Ki-67) strongly suggest that such novel type II cells are pluripotential stem cells in can...